| IPCS Publications WHO/IPCS Publications are available from the following address: Distribution and Sales (DSA) Division of Publishing, Language, and Library Services World Health Organization (WHO) Headquarters CH-1211 Geneva 27 Switzerland Tel: +41 22 791 24 76 / 24 77; Fax: +41 22 791 48 57 For additional information on obtaining EHC Executive Summaries, please contact IPCS at: International Programme for Chemical Safety World Health Organization CH-1211 Geneva 27, Switzerland Tel: +41 22 791 35 88 Fax: +41 22 791 48 48 Information on WHO publications are available at the WHO web site . 1. RISK ASSESSMENT OF PRIORITY CHEMICALS 1.1 EHC Documents: Executive Summaries (Contact IPCS to obtain copies of these documents) Executive Summaries have been prepared for: Environmental Health Criteria documents numbers 2, 3, 4, 5, 7, 8, 10-24, 26 and 35. 1.2 EHC Documents (Contact WHO Distribution and Sales to obtain copies of these documents) | No. 1 | Mercury (1976) | | No. 2 | Polychlorinated biphenyls and terphenyls (1976) | | No. 3 | Lead (1977) | | No. 4 | Oxides of nitrogen (1977) | | No. 5 | Nitrates, nitrites and N-nitroso compounds (1978) | | No. 7 | Photochemical oxidants (1978) | | No. 8 | Sulfur oxides and suspended particulate matter (1979) | | No. 9 | DDT and its derivatives (1979) | | No. 10 | Carbon disulfide (1979) | | No. 11 | Mycotoxins (1979) | | No. 12 | Noise (1980) | | No. 13 | Carbon monoxide (1979) | | No. 14 | Ultraviolet radiation (1979) | | No. 15 | Tin and organotin compounds (1980) | | No. 16 | Radio frequency and microwaves (1981) | | No. 17 | Manganese (1981) | | No. 18 | Arsenic (1981) | | No. 19 | Hydrogen sulfide (1981) | | No. 20 | Selected petroleum products (1982) | | No. 21 | Chlorine and hydrogen chloride (1982) | | No. 22 | Ultrasound (1982) | | No. 23 | Lasers and optical radiation (1982) | | No. 24 | Titanium (1982) | | No. 25 | Selected radionuclides (1983) | | No. 26 | Styrene (1983) | | No. 28 | Acrylonitrile (1983) | | No. 29 | 2,4-Dichlorophenoxyacetic acid (2,4-D) (1984) | | No. 31 | Tetrachloroethylene (1984) | | No. 32 | Methylene chloride (1984) | | No. 33 | Epichlorohydrin (1984) | | No. 34 | Chlordane (1984) | | No. 35 | Extremely low frequency (ELF) fields (1984) | | No. 36 | Fluorine and fluorides (1984) | | No. 37 | Aquatic (marine and freshwater) biotoxins (1984) | | No. 38 | Heptachlor (1984) | | No. 39 | Paraquat and diquat (1984) | | No. 40 | Endosulfan (1984) | | No. 41 | Quintozene (1984) | | No. 42 | Tecnazene (1984) | | No. 43 | Chlordecone (1984) | | No. 44 | Mirex (1984) | | No. 45 | Camphechlor (1984) | | No. 48 | Dimethyl sulfate (1985) | | No. 49 | Acrylamide (1985) | | No. 50 | Trichloroethylene (1985) | | No. 52 | Toluene(1986) | | No. 53 | Asbestos and other natural mineral fibres (1986) | | No. 54 | Ammonia (1986) | | No. 55 | Ethylene oxide (1985) | | No. 56 | Propylene oxide (1985) | | No. 58 | Selenium (1986) | | No. 61 | Chromium (1988) | | No. 62 | 1,2-Dichloroethane (1987) | | No. 63 | Organophosphorus insecticides: A general introduction (1986) | | No. 64 | Carbamate pesticides: A general introduction (1986) | | No. 65 | Butanols - Four isomers (1987) | | No. 66 | Kelevan (1986) | | No. 67 | Tetradifon (1986) | | No. 68 | Hydrazine (1987) | | No. 69 | Magnetic fields (1987) | | No. 71 | Pentachlorophenol (1987) | | No. 73 | Phosphine and metal phosphides (1988) | | No. 74 | Diaminotoluenes (1987) | | No. 75 | Toluene diisocyanates (1987) | | No. 76 | Thiocarbamate pesticides: A general introduction (1988) | | No. 77 | Man-made mineral fibres (1988) | | No. 78 | Dithiocarbamate pesticides, ethylenethiourea and propylenethiourea: A general introduction (1988) | | No. 79 | Dichlorvos (1988) | | No. 80 | Pyrrolizidine alkaloids (1988) | | No. 81 | Vanadium (1988) | | No. 82 | Cypermethrin (1989) | | No. 83 | DDT - Environmental aspects (1989) | | No. 84 | 2,4-D - Environmental aspects (1989) | | No. 85 | Lead - Environmental aspects (1989) | | No. 86 | Mercury - Environmental aspects (1989) | | No. 87 | Allethrins (1989) | | No. 88 | PCDDs and PCDFs (TCDD; dioxins and dibenzofurans) (1989) | | No. 89 | Formaldehyde (1989) | | No. 90 | Dimethoate (1989) | | No. 91 | Aldrin and dieldrin (1989) | | No. 92 | Resmethrins (1989) | | No. 93 | Chlorophenols other than pentachlorophenol (1989) | | No. 94 | Permethrin (1990) | | No. 95 | Fenvalerate (1990) | | No. 96 | d-Phenothrin (1990) | | No. 97 | Deltamethrin (1990) | | No. 98 | Tetramethrin (1990) | | No. 99 | Cyhalothrin (1990) | | No. 100 | Vinylidene chloride (1990) | | No. 101 | Methylmercury (1990) | | No. 102 | 1-Propanol (1990) | | No. 103 | 2-Propanol (1990) | | No. 105 | Selected mycotoxins: Ochratoxins, trichothecenes, ergot (1990) | | No. 106 | Beryllium (1990) | | No. 107 | Barium (1990) | | No. 108 | Nickel (1991) | | No. 110 | Tricresylphosphate (1990) | | No. 111 | Triphenylphosphates (1991) | | No. 112 | Tributylphosphates (1991) | | No. 113 | Fully halogenated chlorofluorocarbons (1990) | | No. 114 | Dimethylformamide (1991) | | No. 115 | 2-Methoxyethanol, 2-ethoxyethanol and their acetates (1990) | | No. 116 | Tributyltin compounds (1990) | | No. 117 | Methyl isobutyl ketone (1990) | | No. 118 | Inorganic mercury (1991) | | No. 120 | Hexachlorocyclopentadiene (1991) | | No. 121 | Aldicarb (1991) | | No. 122 | n-Hexane (1991) | | No. 123 | alpha- and beta-Hexachlorocyclohexanes (1992) | | No. 124 | Lindane (1991) | | No. 125 | Platinum (1991) | | No. 126 | Partially halogenated chlorofluorocarbons (Methane derivatives) (1991) | | No. 127 | Acrolein (1992) | | No. 128 | Chlorobenzene other than hexachlorobenzene (1991) | | No. 129 | Isobenzan (1992) | | No. 130 | Endrin (1992) | | No. 131 | Diethylhexylphthalate (1992) | | No. 132 | Trichlorfon (1992) | | No. 133 | Fenitrothion (1992) | | No. 134 | Cadmium (1992) | | No. 135 | Cadmium - Environmental aspects (1992) | | No. 136 | 1,1,1-Trichloroethane (1992) | | No. 137 | Electromagnetic fields (1992) | | No. 138 | 2-Nitropropane (1992) | | No. 139 | Partially halogenated chlorofluorocarbons (Ethane derivatives) (1992) | | No. 140 | Polychlorinated biphenyls and polychlorinated terphenyls (PCBs and PCTs) (2nd Ed.) (1993) | | No. 142 | Alpha-cypermethrin (1992) | | No. 143 | Methyl ethyl ketone (1993) | | No. 145 | Methyl parathion (1993) | | No. 146 | Dichloropropene, dichloropropane, and DD (1993) | | No. 147 | Propachlor (1993) | | No. 148 | Benomyl (1993) | | No. 149 | Carbendazim (1993) | | No. 150 | Benzene (1993) | | No. 151 | Synthetic organic fibres (1993) | | No. 152 | Polybrominated biphenyls (1994) | | No. 153 | Carbaryl (1994) | | No. 154 | Acetonitrile (1994) | | No. 155 | Biomarkers and Risk Assessment: Concepts and Principles | | No. 156 | Hexachlorobutadiene (1994) | | No. 157 | Hydroquinone (1994) | | No. 158 | Amitrole (1994) | | No. 159 | Glyphosate (1994) | | No. 160 | Ultraviolet radiations (1994) | | No. 161 | Phenol (1994) | | No. 162 | Brominated diphenyl ethers (1994) | | No. 163 | Chloroform (1994) | | No. 165 | Inorganic lead (1995) | | No. 166 | Methyl bromide (Bromomethane) (1995) | | No. 167 | Acetaldehyde (1995) | | No. 168 | Cresols (1995) | | No. 172 | Tetrabromobisphenol A and derivatives (1995) | | No. 173 | Tris(2,3-dibromopropyl)phosphate and bis(2,3-dibromopropyl)phosphate (1995) | | No. 174 | Isophorone (1995) | | No. 175 | Anticoagulant rodenticides (1995) | | No. 176 | 1,2-Dichloroethane (2nd Ed.) (1995) | 1.3 International Chemical Safety Cards Ten series of 70-80 Cards each have been published so far. To obtain Chemical Safety Cards please contact: Office for Official Publications of the European Commission L-2985 LuxembourgFax: +352 48 85 73 / 48 68 17 1.4 Development of Methodology for Health Risk Assessment (Contact WHO Distribution and Sales to obtain copies of these documents) | Principles and methods for evaluating the toxicity of chemicals, Part I. Environmental Health Criteria No. 6 (1978) | | Guidelines on studies in environmental epidemiology. Environmental Health Criteria No. 27 (1983) | | Principles for evaluating health risks to progeny associated with exposure to chemicals during pregnancy. Environmental Health Criteria No. 30 (1984) | | Guidelines for the study of genetic effects in human populations. Environmental Health Criteria No. 46 (1984) | | Summary report on the evaluation of short-term tests for carcinogens (Collaborative study of in vivo tests). Environmental Health Criteria No. 47 (1985) | | Guide to short-term tests for detecting mutagenic and carcinogenic chemicals (ICPEMC). Environmental Health Criteria No. 51 (1985) | | Principles of toxicokinetic studies. Environmental Health Criteria No. 57 (1986) | | Principles for evaluating health risks from chemicals during infancy and childhood: The need for a special approach. Environmental Health Criteria No. 59 (1986) | | Principles and methods for the assessment of neurotoxicity associated with exposure to chemicals. Environmental Health Criteria No. 60 (1986) | | Principles for the safety assessment of food additives and contaminants in food. Environmental Health Criteria No. 70 (1987) | | Principles of studies on diseases of suspected chemical etiology and their prevention. Environmental Health Criteria No. 72 (1987) | | Principles for the Toxicological Assessment of Pesticide Residues in Food. Environmental Health Criteria No. 104 (1990) | | Summary report on the evaluation of short-term tests for carcinogens (Collaborative study on in vivo tests). Environmental Health Criteria No. 109 (1990) | | Principles and methods for the assessment of nephrotoxicity associated with exposure to chemicals. Environmental Health Criteria No. 119 (1991) | | Quality management for chemical safety testing. Environmental Health Criteria No. 141 (1992) | | Principles for evaluating chemical effects on the aged population. Environmental Health Criteria No. 144 (1993) | | Biomarkers and risk assessment: Concepts and Principles. Environmental Health Criteria No. 155 (1993) | | Assessing human health risks of chemicals: Derivation of guidance values for health-based exposure limits. Environmental Health Criteria No. 170 (1994) | 1.5 Other Publications on Activities Undertaken or Supported by IPCS (Contact the sources listed to obtain copies of these documents) | Development and possible use of immunological techniques to detect individual exposure to chemicals (in collaboration with IARC). IARC Internal Technical Report No. 82/001 (1982) | | Approaches to classifying chemical carcinogens according to mechanisms of action (in collaboration with CEC and IARC). IARC Internal Technical Report No. 83/001 (1983) | | Methods for assessing the effects of chemicals on reproductive functions (in collaboration with the Scientific Group on Methodologies for the Safety Evaluation of Chemicals -SGOMSEC). SCOPE 20/SGOMSEC, 1/IPCS Joint Symposia 1, John Wiley and Sons (1983) | | Methallothionein and cadmium nephrotoxicity. Environmental Health Perspectives, Vol. 54, IPCS Joint Symposia 4 (1984) | | Monitoring human exposure to carcinogenic and mutagenic agents. IARC Scientific Publications No. 59 - IPCS Joint Symposia 7 (1984) | | Nickel in the human environment. IARC Scientific Publications No. 53 (1984) | | Mutation, cancer and malformation. Environmental Science Research, Vol. 31, Plenum Press (1984) | | Methods for estimating risks of chemical injury: Human and non-human biota and ecosystems (in collaboration with SGOMSEC). SCOPE 26/SGOMSEC 2/IPCS Joint Symposia 3, John Wiley and Sons (1985) | | Evaluation of short-term tests for carcinogens. Report of the IPCS Collaborative Study of in vitro assays for genotoxicity. (Progress in Mutation Research, Vol. 5), Elsevier Science Publishers (1985) | | Evaluation of methods for assessing human health hazards from drinking water (in collaboration with CEC, IARC, the Mission for Study and Research/French Ministry of Environment, and the National Institute for Water Supply, The Netherlands). IARC Internal Technical Report No. 86/001 (1986) | | Hexachlorobenzene. Proceedings of an International Symposium held at IARC, Lyon, France, 24-28 June 1984 (in collaboration with IARC, CEC, US EPA and the US National Cancer Institute) IARC Scientific Publications No. 77 (1986) | | Toxicologie clinique: Formation du personnel infirmier. Forum organized in Brussels, 5-7 November 1984 (in collaboration with the CEC and World Federation of Associations of Clinical Toxicology and Poison Control Centres) Cahiers de Toxicologie clinique et expérimentale, 1986, No. 3 | | Long-term and short-term assays for carcinogens: A critical appraisal (in collaboration with IARC). IARC Scientific Publications No. 83 (1986) | | Environmental toxicology and ecotoxicology. Proceedings of the Third International Course, Edinburgh, United Kingdom, 6-13 September 1985 EURO Environmental Health Series No. 10 (1986) | | The health effects of aromatic amines - A review (prepared by MARC, London, on behalf of IPCS). MARC Report No. 35 (1986) | | Methods for the assessment of the toxicity evaluation of mixtures of chemicals (in collaboration with SGOMSEC). SGOMSEC 3/IPCS Joint Symposia 6, John Wiley and Sons (1987) | | Immunotoxicology. Proceedings of the International Seminar on the Immunological System as a Target for Toxic Damage - Present Status, Open problems and Future Perspectives (in collaboration with CEC, US EPA, NIEHS and the International Society of Immunopharmacology). IPCS Joint Seminar 10, Martinus Nijhoff Publishers (1987) | | Indicators for assessing exposure and biological effects of genotoxic chemicals: Consensus and technical reports. Proceedings of an International Workshop on Indicators in Human Biological Materials for Assessing Exposure to and/or Biological Effects of Genotoxic Chemicals, Luxembourg, 6-9 July 1987 (in collaboration with the CEC, WHO/EURO, and the Institute of Occupational Health, Finland) EUR 11642 EN (1988) | | Results of the survey of poison control centres and related toxicological services, 1984-1986 (in collaboration with the CEC and the World Federation of Associations of Clinical Toxicology and Poison Control Centres) Journal de Toxicologie clinique et experimentale: Toxicovigilance - Centre anti-poisons, September-October 1988, No. 5 | | Major hazard control: A practical manual An ILO contribution to IPCS (1988) | | Evaluation of short-term tests for carcinogens. Report of the IPCS Collaborative Study on in vivo assays - Volumes I and II, Cambridge University Press (1989) | | Ecotoxicology and climate, with special reference to hot and cold climates, SCOPE 38/IPCS Joint Symposia 9, John Wiley and Sons (1989) | | Methods for assessing and reducing injury from chemical accidents (in collaboration with SGOMSEC). SCOPE 40/SGOMSEC 6/IPCS Joint Symposia 11, John Wiley and Sons (1989) | | Glossary of terms on chemical safety for use in IPCS publications (WHO/ICS/89.27) (1989) | | Health significance and early detection of nephrotoxicity. Proceedings of the Joint CEC/IPCS/ Workshop held in Luxembourg, 26-29 April 1988 Toxicology Letters, Vol. 46, Issue No 1-3, IPCS Joint Symposia 12 (1989) | | Information useful for the identification of hazards during the manufacture, storage, transport, use, and disposal of substances: An annotated checklist (WHO/PCS/90.41) (1990) | | Predictive value of short-term tests for non-genotoxic effects (in collaboration with SGOMSEC). SGOMSEC 4/IPCS Joint Symposia 8, John Wiley and Sons (1990) | | Immunotoxicity of metals and immunotoxicology. Proceedings of an international workshop held in Hanover, 6-10 November 1989, EUR 12764 EN, IPCS Joint Symposia 15, Plenum Press (1990) | | Public health impact of pesticides used in agriculture WHO (1990) | | Proceedings of the International Workshop on Kashin-Beck Diseases and Non-Communicable Diseases held in Beijing, 28 October-1 November 1985, WHO (1990) | | Methods for assessing exposure of human and non-human biota (in collaboration with SGOMSEC). (SCOPE 46/SGOMSEC 5/IPCS Joint Symposia 13), John Wiley and Sons (1991) | | Proceedings of the Joint ECETOC/IPCS Workshop on Early Indicators of Non-Genotoxic Carcinogenesis held in Brussels, 19-20 June 1990 Mutation Research, Vol. 248, special issue No. 2, IPCS Joint Symposia 14 (1991) | | Safety and health in the use of agrochemicals: A guide An ILO contribution to IPCS (1991) | | Prevention of major industrial accidents: An ILO code of practice. An ILO contribution to IPCS (1991) | | Occupational exposure limits for airborne toxic substances, 3rd Ed. Occupational Safety and Health Series 37. An ILO contribution to IPCS (1991) | | Proceedings of the African Workshop on Health Sector Management in Technological Disasters, Addis Ababa, 26-30 November 1990 (1991) | | Methods for assessing exposure of human and non-human biota (in collaboration with SGOMSEC). (SCOPE 46/SGOMSEC 5/IPCS Joint Symposia 13), John Wiley and Sons (1991) | | Mutagenicity of complex mixtures in Salmonella typhimurium. A report of the International Programme on Chemical Safety's collaborative study on complex mixtures Mutation Research, Vol. 276, Special issue, Nos 1/2 (1992) | | Chemical safety. Training module No. 1: Fundamentals of applied toxicology - The nature of chemical hazards (WHO/PCS/92.3) (1992) | | Final report of the Steering Group on naturally occurring toxins of plant origin, Carshalton, UK, 20-22 May 1992 (IPCS/International Life Sciences Institute, Europe) (WHO/PCS/92.69) (1992) | | Mycotoxins and Balkan endemic nephropathy Food and Chemical Toxicology, Vol. 30, No. 3 (March 1992) | | IPCS/INTOX Project - Poisons Information Monograph: Brodifacoum (IPCS/INTOX/PIM.077) (1992) | | IPCS/INTOX Project - Poisons Information Monograph: Cyanides (IPCS/INTOX/PIM.159) (1992) | | IPCS/INTOX Project - Poisons Information Monograph: N,N-Diethyltoluamide (IPCS/INTOX/PIM.170) (1992) | | IPCS/INTOX Project - Poisons Information Monograph: Thallium (IPCS/INTOX/PIM.525) (1992) | | IPCS/INTOX Project - Poisons Information Monograph: Pseudechis (Black snakes) (1993) | | IPCS/INTOX Project - Poisons Information Monograph: Notechis (Tiger snake) (1993) | | IPCS/INTOX Project - Poisons Information Monograph: Oxyuranus (Taipan) (1993) | | IPCS/INTOX Project - Poisons Information Monograph: Pseudonaja (Brown snake) (1993) | | IPCS/INTOX Project - Poisons Information Monograph: Funnel Web Spiders (1993) | | How to use the Health and Safety Guides. Pre-publication version, May 1993 (PEP/PCS/93.15) (1993) | | Safety and health in the use of chemicals at work: A training manual. An ILO contribution to IPCS (1993) | | Chemical safety. Metabolism and Toxicity: Collected lectures (WHO/PCS/93.41) (1993) | | Report of the Informal Consultation on the Safety of Microbial Pest Control Agents, WHO, Geneva, 23-26 June 1993 (WHO/PCS/93.47) (1993) | | Chemical safety matters, IPCS/International Union of Pure and Applied Chemistry (IUPAC), Cambridge University Press (1993) | | Health aspects of chemical accidents. Guidance on chemical accident awareness, preparedness and response for health professionals and emergency responders (OECD Environment Monograph No. 81 - UNEP IE/PAC Technical Report No. 19) (OCDE/GD (94)1) (1994) | | The WHO recommended classification of pesticides by hazard and guidelines to classification 1994-1995 (WHO/PCS/94.2) (1994) | | Multilevel course on the safe use of pesticides and on the diagnosis and treatment of pesticide poisoning (WHO/PCS/94.3) (1994) | | Chemical safety: Training modules (ILO/IPCS) (1994) | | Respiratory toxicology and risk assessment. Proceedings of an International Symposium (IPCS Joint Series 18) Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart | | Abstract book: Mycotoxins and toxic plant components - EC, WHO/IPCS, FAO and ILSI Europe Joint Workshop, Lisbon, Portugal, 13-15 October 1994 | | Environmental monitoring for genotoxicity with plant systems Mutation Research, Vol. 310, No. 2, Special issue (1994) | | Proceedings of the IPCS/UK DOH International Workshop on Environmental Immunotoxicology and Human Health, London, 22-25 March 1994 Human and Experimental Toxicology, Vol. 14, No. 1 (IPCS Joint Series 17) (1995) | | Joint Meeting on Pesticides. Report of the 1995 meeting of the Core Assessment Group (WHO/PCS/95.7) (1995) | | Summary of evaluations performed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), 1956-1993 (First through Forty-first meetings), WHO (1994) | | Basic analytical toxicology, WHO (1995) | | IPCS/INTOX package, Canadian Centre for Occupational Health and Safety (CCOHS) (1995) | | Methods to assess the effects of chemicals on ecosystems (in collaboration with SGOMSEC), SCOPE 53/SGOMSEC 10/IPCS Joint Activity 23, John Wiley and Sons (1995) | | IPCS - Summary of toxicological evaluations performed by the Joint Meeting on Pesticide Residues (JMPR) through 1995 (WHO/PCS/95.50) | | Allergic hypersensitivities induced by chemicals: Recommendations for prevention (WHO Regional Office for Europe/IPCS), CRC Press, Inc. (1996) | |