This is the third volume of a three-volume final report, which thoroughly describes, synthesizes and analyzes the results of the four-year Integrated Research Project CIRCE – Climate Change and Impact Research: Mediterranean Environment, funded by the EU 6th Framework Programme. Conducted under the auspices of the National Institute of Geophysics and Volcanology in Rome, Italy, the study was designed to predict and to quantify the physical impacts of climate change in the Mediterranean, and to assess the most influential consequences for the population of the region. Volume 3 is dedicated to the results of case-studies performed in CIRCE. These provide interesting additional materials to the assessments in the other parts and certainly they represent a rare example of integrated analysis of the impact of climate change. The case studies collected here represent urban, rural and coastal environments, drawn from the north and the south of the Mediterranean shore. Discussion also includes the involvement of stakeholders, the level of engagement and the data and knowledge indicators used in the assessment and adaptation strategies.